Long-term exposure to hydrogen sulfide decreases body temperature to 31°C and induces a torpor-like state. We are using this method to diminish post-stroke inflammation
J Cereb Blood Flow Metab. 2012 Aug;32(8):1632-42. doi: 10.1038/jcbfm.2012.65. Epub 2012 May 23.
Prolonged gaseous hypothermia prevents the upregulation of phagocytosis-specific protein annexin 1 and causes low-amplitude EEG activity in the aged rat brain after cerebral ischemia.
Joseph C1, Buga AM, Vintilescu R, Balseanu AT, Moldovan M, Junker H, Walker L, Lotze M, Popa-Wagner A.
G-CSF, a multimodal acting, versatile factor
G-CSF treatment after stroke significantly improved mortality rate and performance in several but not all functional tests.
G-CSF Treatment Improved Neurogenesis in the Dentate Gyrus
Stroke Cell Therapy: flow diagram
REFERENCE
Front Aging Neurosci. 2014 Jun 23;6:130. doi: 10.3389/fnagi.2014.00130.
eCollection 2014. Multimodal Approaches for Regenerative Stroke Therapies: Combination of
Granulocyte Colony-Stimulating Factor with Bone Marrow Mesenchymal Stem Cells is
Not Superior to G-CSF Alone.
Balseanu AT, Buga AM, Catalin B, Wagner DC, Boltze J, Zagrean
AM, Reymann K, Schaebitz W, Popa-Wagner A.
Beam-walking test: Both G-CSF alone and the combination therapy improved performance vs controls
REFERENCE
Front Aging Neurosci. 2014 Jun 23;6:130. doi: 10.3389/fnagi.2014.00130. eCollection 2014.
Multimodal Approaches for Regenerative Stroke Therapies: Combination of Granulocyte Colony-Stimulating Factor with Bone Marrow Mesenchymal Stem Cells is Not Superior to G-CSF Alone. Balseanu AT, Buga AM, Boltze J, Schaebitz W, Popa-Wagner A.